"" Ralph W. Moss, Ph.D., Cancer Advisor

Monday, January 30, 2012

FDA Approves First Drug for Advanced BCC Skin Cancer

Jan. 30--The Food and Drug Administration (FDA) today approved a drug for the treatment of advanced basal cell carcinoma (BCC). This is the first drug ever approved for this condition and so I think this is important news. The name of the drug is vismodegib (trade name Erivedge®). It is marketed by the international drug giant Roche and its American subsidiary, Genentech. Erivedge is classified as a "hedgehog inhibitor," a new class of drugs.

In a clinical trial at the Karamanos Cancer Center, Detroit, published last year, it shrank these advanced skin tumors in 19 out of 33 cases (57.6%). There was preliminary evidence of activity in medulloblastoma (i.e., a kind of brain cancer). Grade 3 and 4 (serious or severe) adverse effects were also common (affecting almost 37% of patients).

The FDA approval of Erivedge is based on results from ERIVANCE BCC (SHH4476g), an international, single-arm, multicenter, two-cohort, open-label, Phase II study that enrolled 104 patients with advanced BCC, including locally advanced BCC (71) and metastatic BCC (33).

This study showed that Erivedge shrank lesions (i.e., had an objective response rate) in 43 percent (27/63) of patients with locally advanced BCC and 30 percent of patients (or 10/33) with metastatic BCC, as assessed by independent review, the primary endpoint of the study. The median duration of response was 7.6 months.

The pill will come at a steep price: $7,500 per month or $75,000 for a typical 10-month course. It is currently approved for patients with early stage BCC who cannot be treated with surgery or radiation.

LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin. Cancer Res. 2011;17(8):2502-2511.

Wednesday, June 8, 2011

Another Phone Consultee Speaks

As you may know, I do phone consultations for cancer patients almost every day. I was very pleased to receive this feed-back comment the other day:

"When one receives a diagnosis of metastatic cancer all of a sudden you are thrust crudely into a new world of questions, doubt, fear and loathing. Ralph Moss is a bright mind and steady hand in providing trusted information in a way that one can sort things out and decide a pathway whether it be traditional Western Medicine or a Homeopathic approach. He can help confirm or deny your logical thoughts and your gut level instincts relative to the eventual decisions you will need to make." --T.T.

If I can be of help to you please call my assistant Jacquie Johnson at 814-466-6514 to make an appointment.

Tuesday, May 3, 2011

An MD Consultee Speaks

I have been doing many phone consultations lately, which is one of the reasons I have been remiss in adding entries to this blog. Everyone of my consultations is important to me and we always ask for feedback. Yesterday I did a consultation with a medical doctor and his wife (also a medical doctor). I was happy to help in this couple's decision making process. So here the response of one busy doctor to our consultation:

"Fabulous phone consult. Lots of suggestions, names & phone numbers of specialists to contact specific to my problem. Well worth the time and cost." —B.W., May 2, 2011

Tuesday, March 29, 2011

A Phone Consultee Speaks

As you may know, each day I do phone consultations for cancer patients. Today I got this nice comment from S.R., one of my recent consultees. She wrote as follows:

"At one point, I was reading 5 books simultaneously, on nutrition alone. Then I found out about Mr. Ralph Moss and Cancer Decisions website and started getting acquainted with his work. I purchased a report on my kind of cancer, read it, and later scheduled a conversation with Mr. Moss. The whole experience was eye-opening for me. He saved me months, maybe years of doing my own research. And still, I would never been able to find out everything he has written about. Mr. Moss has amazing insight not only in alternative therapies but also in nutrition. I am truly grateful! Now, I can make an informed decision about my health and future. Thank you again!"

Thursday, March 3, 2011

Vegan contest

It's getting a lot easier to find vegetarian and vegan food in many parts of the country!

- Posted using BlogPress from my iPhone

Location:Florida 7,Sunshine Parkway,United States

Wednesday, March 2, 2011

Going to Florida

I am about to get on a plane for the 4th annual Annie Appleseed conference on complementary cancer treatment. I will follow this with two lectures at the A4M Cancer Modules course and a visit to the IAT clinic in the Bahamas. A busy and instructive week!

- Posted using BlogPress from my iPhone

Location:West Palm Beach

Friday, February 18, 2011

Curcumin and Turmeric

Many people take turmeric or curcuminoids for their anti-inflammatory and/or anticancer properties. But how accurate are the labels?

Consumerlabs.com recently evaluated 10 popular turmeric and curcumin supplements. They found that two of them were underpowered. "Advance Physician Formulas" claimed that their supplement contain 245 mg of curcumin. But they only contain 18.9 mg! Similarly, Paradise Herbs and Essential Turmeric is said to contain 125 mg of curcuminoids per capsule. But it only contains 18.4 mg (or 14.7 percent of the stated amount).

The good news was that all the other brands delivered what they promised. This includes such well known brands as Solgar, Swanson, Jarrow and GNC. Life Extension Super Curcumin with Bioperene was also as advertised. It is a good bargain as well, 17 cents per 500 mg of curcuminoids. It contains BioPerine, which aids adsorption. (By way of disclosure, I am on the Life Extension Foundation's Scientific Advisory Board.)