"" Ralph W. Moss, Ph.D., Cancer Advisor: Israeli Supplement Targets Colon Cancer

Saturday, November 6, 2010

Israeli Supplement Targets Colon Cancer

[caption id="attachment_89" align="alignnone" width="300" caption="Tel Aviv scientists pioneer food supplement"][/caption]

A new food supplement from Israel targets colon and rectal cancer, as well as ulcerative colitis and other bowel diseases. The product, which has yet to hit the world market, is called Coltect. It is a combination of green tea polyphenols, curcumin powder from the turmeric root and the trace mineral selenium. Its effects were described at a recent oncology meeting and it is the subject of two clinical trials.

Results were presented at the 2010 American Society for Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium. The authors, from Tel Aviv Sourasky Medical Center, tried Coltect alone or combined with a common drug, 5-aminosalicylic acid (5-ASA), in cell line and animal models of colon cancer.

Depending on the dose, there was up to an 83 percent inhibition of cancer cell growth using Coltect. In the animal model, the combination of Coltect and the drug 5-ASA reduced the number of precancerous lesions from 66.5 in the control group to 20 in the group that received both agents. The authors concluded that Coltect "can be administered as a chemopreventive regimen to prevent" colorectal cancer.

While waiting for Coltect to hit the world market, one might consider taking a combination of green tea polyphenols, turmeric (with its key ingredient, curcumin) and Brazil nuts (a good source of selenium--use the kind that you have to shell yourself).

As for 5-ASA, it is not available without a prescription. But it is a derivative of salicylic acid and is chemically similar to aspirin. A 2003 journal article concluded: "Preclinical, observational, and clinical data consistently show that non-steroidal anti-inflammatory drugs (NSAIDs)—particularly aspirin—reduce colorectal carcinogenesis" (Hawk and Vine, 2003). So you might ask your doctor about taking a baby aspirin (81 mg) along with the anticancer food components.

Colon cancer afflicts over 100,000 Americans each year. Perhaps some of these cases could be prevented by the judicious use of anticancer foods, supplements and drugs, all of which are readily available. The toxicity of such agents is low and the cost of all together is less than a dollar a day.

References:

http://clinicaltrials.gov/ct2/show/NCT00793130

http://biopromedical.com/Coltect.html

http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=72&abstractID=1745

Hawk ET, Viner JL. Aspirin: still learning about the wonder drug. Gut. 2003;52(11):1535-1536.

8 comments:

  1. You say that we might "consider taking a combination of green tea polyphenols, turmeric (with its key ingredient, curcumin) and Brazil nuts ... ". How much of each per day? Will drinking a cup of green tea, putting 1/2 teaspoon of turmeric in my soup, and eating a whole, freshly shelled Brazil nut do it?
    Thanks,
    Rahel

    ReplyDelete
  2. I am not a medical doctor and so cannot prescribe anything, including supplements. However, I myself aim at (1) one pot of green tea, spaced out over the day, (2) at least two Brazil nuts, of the unshelled variety. I shell them myself as I believe that those that are already shelled lack the desire selenium; and (3) either a hefty dose of turmeric in food or else a curcumin supplement pill. Hope that is helpful.

    ReplyDelete
  3. THANK YOU FOR THIS ARTICLE AND REPLY. How much green tea (dry) do you use in making a "pot"? Thnx

    ReplyDelete
  4. It is about one tablespoon, more or less. Of course you have to make it palatable so that you enjoy drinking it. I generally use a high grade of green tea, such as Rishi Tea organic green tea.

    ReplyDelete
  5. "I shell them myself as I believe that those that are already shelled lack the desire selenium..."

    I've never heard this before. What leads you to think so?

    I use matcha green tea, the kind used in the traditional Japanese tea ceremony. It takes much less tea to get a polyphenol "dose" because, with matcha, the tea is in powder form and it is not steeped but actually consumed. Ie, you add hot water to the powdered tea, stir, and drink.

    I make a drink using a tablespoon of straight cocoa (not cocoa "mix") and a bit less than a half teaspoon of matcha tea. It's easily prepared a cup at a time, and takes only the time required to heat water to 140 degrees.

    For specificity, the kind of tea I use is Vita-Life Matcha from Amazon. There are lots of other kinds.

    ReplyDelete
  6. Would selenium supplements work as effectively as the shelled Brazil nuts?

    ReplyDelete
  7. Curcumin in raw turmeric not very bioavailable, but the absorbtion is increased when it's cooked. I found a scientific publication to this effect, but don't have it on this computer. Bear in mind that traditional uses of turmeric cook it - either in food (curries), or in herbal decoctions. Eating curry is one way, then. Adding turmeric to rice etc while cooking is another. Yes, black pepper (piperine) is reported to improve absorption. For some folk, however, it may burn on the way out (as do some curries.) Piperine is a stronger agonist of the vanilloid receptor site than is capsaicin.

    ReplyDelete
  8. Is the Coltect that was mentioned in the Israel article the same product as the Cellect being sold in the US? I met someone with advanced colon cancer who is doing very well on the Cellect-Budwig protocol.

    ReplyDelete