"" Ralph Moss—Cancer Consultant: 2015-10-18

Friday, October 23, 2015

ECTO-NOX Proteins: Growth, Cancer and Aging (Book Review)


ECTO-NOX PROTEINS:
GROWTH, CANCER AND AGING

© 2015 by Ralph W. Moss, PhD

Once in a rare while a scientific book comes along that, while highly technical in nature, also contains information of urgent importance to patients and their caregivers. Such a book is ECTO-NOX Proteins: Growth, Cancer and Aging (Springer 2013). This astonishing book offers a detailed and well-organized record of five decades of research by the husband-and-wife team of D. James Morré, PhD and Dorothy Morré, PhD, mainly conducted as professors at Purdue University in West Lafayette, Indiana. James Morré, the Dow Professor of Medicinal Chemistry, was the founding director of Purdue’s cancer research center.



In this groundbreaking book, the Morrés explain the global significance of a class of proteins called “ECTO-NOX,” which is commonly abbreviated ENOX. The “ECTO” prefix means that these various proteins, regardless of where their originating genes reside, are ultimately expressed on the surface or exterior of cells (from the ancient Greek ectos, “outside”). There are presently three known classes of ENOX proteins. ENOX1 is a normal constituent of most cells. ENOX2 is found in cancer of many kinds. ENOX3, also called arNOX, is an age-related class of proteins. These various ENOX proteins are crucially involved in cell growth, biological time keeping, cancer, aging and even viral infections. They also share some similarities to prions, which are proteins that are responsible for a number of human illnesses (such as “mad cow disease”). 



James Morré, PhD
These proteins are unique in a number of ways. For instance, their expression depends on a particular biological clock, or circadian rhythm, that (depending on the form of ENOX) varies from 22 to 26 minutes. They alternately carry out two separate physiological functions in rapid succession. The explanation in this book of these peculiarities is very clear and will strike most readers with a background in science as revolutionary in its implications for basic biology.



Particularly thought provoking are the Morrés’ discussions of ENOX2 and ENOX3. ENOX2 is specific for cancer and plays an indispensable role by allowing an immature cancer cell to enlarge to a normal size. The Morrés spent decades perfecting a practical test for ENOX 2, which is now called ONCOblot. This test can reputedly differentiate among 26 different types of cancer. According to oncoblotlabs.com, the test can detect tumors as small as 1 mm in diameter, which represents about 2 million cells. This makes it about ten times more sensitive than a typical Positron Emission Tomography (PET) scan. If cancers can be detected at this early stage, and differentiated as to tissue of origin, then this alone represents a huge advance in the cancer field. It would allow for the possibility of early detection and then medical intervention to eliminate small tumors before they become increasingly difficult to treat. 

Dorothy Morré, PhD



James Morré told me that he and his wife refused to release the ONCOblot test to the public until they had discovered a way to convert an elevated test score back to normal, presumably by curing very early stage cancers (personal communication, July 2015). 
The practical upshot of this is a pill called Capsol-T. This is a 25:1 mixture of decaffeinated green tea powder and a low-heat guajillo red pepper. The red pepper potentiates the activity of the green tea ten- to one hundred-fold. In a clinical trial involving 110 subjects, 40 percent of them tested positive for ENOX2 on ONCOblot. They then took Capsol-T for around four months. They took it around the clock, every four hours (using a sustained release form before bedtime). The result was that 94 percent no longer showed as positive for ENOX2 on a repeat test. They were presumably cured of early-stage, non-clinical cancer.

Green tea is no stranger to the world of medical research. There are presently ~2,000 articles on the topic in PubMed, 1,337 of which involve the main catechin, EGCg. But while Capsol-T might sound like just another empirical cancer remedy, its use is based upon a prolonged and intensive scientific study, based around its ability to inhibit ENOX2. There was nothing haphazard about the way these food constituents were put together. It turns out to be the most effective natural inhibitor of ENOX2 in cancer cells. Its own activity is enhanced between 10 and 100 times by the concurrent administration of a small amount of red pepper. In fact, in the laboratory this combination is almost as effective as the powerful (and toxic) chemotherapy drug, Adriamycin, at inhibiting ENOX2. 

I hope the reader now senses the enormous potential of this line of research, the fruit of more than 50 years of determined work at Purdue and elsewhere. (James Morré himself has published 399 PubMed-indexed scientific papers.) If we now truly have a way to detect very early cancers, differentiate their tissue of origin, and then treat and eliminate them in their preclinical stages, I believe that the Morrés have gone a long way to solving the cancer puzzle! This proposition of course requires further testing. But, at this point, the burden of proof shifts from these individuals to the large and well-funded government and private agencies, which have the capacity to carry out large-scale tests. The fact that they have not done so is both puzzling and frustrating. One hopes this is not another instance of the determined suppression of a generic and non-toxic approach in the interest of entrenched medical interests.

ENOX3 AND AGING



The Morrés’ discussion of aging will be revelatory for those who are concerned about the ravages of time on the human organism. The Morrés also identified a substance called ENOX3, also called the age-related ENOX (abbreviated arNOX), which is similar in its fundamental structure to ENOX2, although it originates from genes on different chromosomes. ENOX3 begins to appears at around age 30, and then increases into one’s 60s or 70s. The amount of ENOX3 in blood or saliva correlates quite strongly with one’s apparent age. In other words, the more ENOX3 one has, the older one looks. 


In the laboratory, the Morrés have discovered that certain readily available, non-toxic substances strongly inhibit the destructive effects of ENOX3, thus suppressing one of the mainsprings of the aging process. Key among these is coenzyme Q10. CoQ10 is made in the human body but is also widely available as a food supplement. 

Another surprising fact in this book is that certain herbs are protective against ENOX3. These are especially the famous French mixture, the herbs de Provence. This a mixture of dried herbs that are typical of the Provence region of southeast France. But the Morrés discovered that the most effective and beneficial of these herbs is summer savory (Satureja hortensis). These herbs are very active in human biology, even at the minute levels used in French cooking. I presently use both the dried and fresh forms of these herbs and intend to keep cultivating them, especially savory, indoors throughout the winter months.



In sum, since 1960, the scientists James and Dorothy Morré have produced an amazing body of scientific work, which they have summarized with admirable clarity in this 500-page text. The book contains more than 1,000 scientific references, many of them by the Morrés, their students and coworkers at Purdue University, as well as a very useful and detailed index. Hats off also to the publisher, Springer, since I could not find a single typographical error in the entire book (a rare publishing achievement these days). 

Some of the explanations in ECTO-NOX Proteins are by necessity very detailed and specialized and so non-specialist readers may find themselves skipping over some  technical discussions. But the general thrust of the argument is not hard to follow. Once you understand what is at stake in this line of research, you will read this book as the great scientific detective story that it is. If you have an intense interest in questions of growth, cancer or aging, or want to learn more about the anti-cancer and anti-aging potential of ENOX protein inhibitors, you definitely will not want to miss this groundbreaking book.
NOTE: My only caveat about this book is the price, which is $267 on Amazon ($219 on Kindle). However, readers of this article can obtain a hardcover copy of ECTO-NOX Proteins from the Harvey H. and Donna M. Morré Foundation for Cancer Research, 1112 Cherry Lane, West Lafayette, IN 47906 by enclosing a check for a donation of $100 to the foundation and providing a mailing address.

For the Morrés cancer test and treatment:

Oncoblot test: http://oncoblotlabs.com/

Capsol-T treatment: http://www.capsol-t.com/